CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS
摘要
A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.
申请公布号
WO2011119922(A1)
申请公布日期
2011.09.29
申请号
WO2011US29934
申请日期
2011.03.25
申请人
WATERS TECHNOLOGIES CORPORATION;BUNNER, BERNARD;DOURDEVILLE, THEODORE, A.