发明名称 |
LIPOSOMES COMPRISING AMPHIPATHIC DRUGS AND METHOD FOR THEIR PREPARATION |
摘要 |
The present invention provides a liposome having co-encapsulated in its intraliposomal aqueous core at least two amphipathic drugs, the liposomes being characterized by one of the following: the amphipathic drugs are co-encapsulated at a pre-determined ratio; the liposome comprises one or a combination of liposome forming lipids have a solid ordered to liquid disordered phase transition temperature above 37°C; each of the amphipathic drugs exhibit a liposomal profile that corresponds to the profile of each drug when encapsulated as a single drug in the same liposome; and the liposome is absent of one or both of a transition metal and a ionophore. The invention also provides a method for preparing such liposomes. This method, taken together with the features of the liposomal composition, provides high loading and long term stability of the resulting co-encapsulated liposomal formulation. |
申请公布号 |
WO2011092708(A3) |
申请公布日期 |
2011.09.29 |
申请号 |
WO2011IL00114 |
申请日期 |
2011.02.01 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM, LTD.;BARENHOLZ, YECHEZKEL;ZUCKER, DANIEL |
发明人 |
BARENHOLZ, YECHEZKEL;ZUCKER, DANIEL |
分类号 |
A61K9/127;A61K31/4745;A61K31/475 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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