发明名称 |
STRUCTURED PEPTIDE PROCESSING |
摘要 |
The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage. |
申请公布号 |
SG173169(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
SG20110054392 |
申请日期 |
2010.02.04 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
WINTER, PAUL, GREGORY;HEINIS, CHRISTIAN;BERNARD, ELISE;LOAKES, DAVID;VAYSBURD, MARINA |
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