发明名称 |
EP4 Receptor Agonist, Compositions and Methods Thereof |
摘要 |
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts. |
申请公布号 |
US2011237511(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US201113152586 |
申请日期 |
2011.06.03 |
申请人 |
MERCK FROSST CANADA |
发明人 |
BILLOT XAVIER;COLUCCI JOHN;HAN YONGXIN;WILSON MARIE-CLAIRE;YOUNG ROBERT N. |
分类号 |
A61K38/23;A61K31/4412;A61K31/45;A61K31/4535;A61K31/454;A61K31/4704;A61K31/535;A61K31/5377;A61K31/558;A61K31/565;A61K31/59;A61K38/17;A61P7/10;A61P9/12;A61P19/08;A61P19/10;A61P27/02;A61P27/06;A61P35/00;A61P35/04;C07D211/54;C07D211/74;C07D211/76;C07D265/04;C07D265/10;C07D279/06;C07D401/06;C07D409/06 |
主分类号 |
A61K38/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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