发明名称 |
VACCINES COMPRISING MUTANT ATTENUATED INFLUENZA VIRUSES |
摘要 |
The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain.
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申请公布号 |
US2011236417(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US201113070110 |
申请日期 |
2011.03.23 |
申请人 |
WARF - WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
WATANABE SHINJI;WATANABE TOKIKO;KAWAOKA YOSHIHIRO |
分类号 |
A61K39/145;A61P31/16;A61P37/04 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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