发明名称 |
GENETICALLY RECOMBINANT ANTIBODY COMPOSITION CAPABLE OF BINDING SPECIFICALLY TO GANGLIOSIDE GM2 |
摘要 |
The present invention relates to a genetically recombinant antibody composition which specifically binds to ganglioside GM2, which has higher complement-dependent cytotoxic activity than a human IgG1 antibody and a human IgG3 antibody, wherein a polypeptide comprising a CH2 domain in the Fc region of a human IgG1 antibody is replaced by a polypeptide comprising an amino acid sequence which corresponds to the same position of a human IgG3 antibody indicated by the EU index as in Kabat, et al.; a DNA encoding the antibody molecule or a heavy chain constant region of the antibody molecule contained in the recombinant antibody composition; a transformant obtainable by introducing the recombinant vector into a host cell; a process for producing the recombinant antibody composition using the transformant; and a medicament comprising the recombinant antibody composition as an active ingredient.
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申请公布号 |
US2011236374(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US20080524215 |
申请日期 |
2008.01.24 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
SHITARA KENYA;NIWA RINPEI;NATSUME AKITO |
分类号 |
A61K39/395;A61P35/00;C07H21/04;C07K16/18;C12N5/10 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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