<p>This application discloses compounds according to general Formula (A) wherein, variable Z* is defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula (A) and at least one carrier, diluent or excipient.</p>
申请公布号
SG173816(A1)
申请公布日期
2011.09.29
申请号
SG20110060654
申请日期
2010.02.25
申请人
F. HOFFMANN-LA ROCHE AG
发明人
BERTHEL, STEVEN JOSEPH;FIROOZNIA, FARIBORZ;FISHLOCK, DANIEL;HONG, JUN-BAE;LOU, YAN;LUCAS, MATTHEW C.;OWENS, THIMOTHY D.;SARMA, KESHAB;SWEENEY, ZACHARY KEVIN;TAYGERLY, JOSHUA PAUL GERGELY