Process for the preparation of Gabapentin

摘要

The present patent application discloses a method for the preparation of [(1-aminomethyl)cyclohexyl]acetic acid (Gabapentin) by means of the Hofmann re-arrangement reaction and the extraction of the Gabapentin from the reaction mixture with a higher aliphatic alcohol, wherein the Hofmann reaction is conducted continuously, for the purpose of obtaining an active ingredient with a good yield and a quality suitable for use in the preparation of pharmaceutical products.