发明名称 |
INFARCT AREA PERFUSION-IMPROVING COMPOSITION |
摘要 |
The described invention provides pharmaceutical compositions for treating an infarct area injury and methods of treating or repairing the infarct area injury in a revascularized subject in the aftermath of an acute myocardial infarction resulting from a natural disease process by administering to the subject parenterally through a catheter a sterile pharmaceutical composition containing a therapeutically effective amount of a nonexpanded sterile isolated chemotactic hematopoietic stem cell product as a first therapeutic agent and optionally a therapeutically effective amount of at least one compatible second therapeutic agent. The infarct area-improving amount of the sterile isolated chemotactic hematopoietic stem cell product comprises an enriched population of isolated autologous CD34+ cells containing a subpopulation of potent cells expressing CXCR-4 and having CXCR-4-mediated chemotactic activity such that the enriched population of isolated autologous CD34+ hematopoietic stem cells provides at least 0.5×106 potent CD34+ cells expressing CXCR-4 and having CXCR-4 mediated chemotactic activity. |
申请公布号 |
EP2367432(A1) |
申请公布日期 |
2011.09.28 |
申请号 |
EP20090831024 |
申请日期 |
2009.12.02 |
申请人 |
AMORCYTE, INC. |
发明人 |
PECORA, ANDREW;PRETI, ROBERT |
分类号 |
A61K35/14;A61K31/155;A61K31/22;A61K31/4439;A61K31/5375;A61K35/16;A61K35/28;A61K38/08;A61K38/10;A61K38/17;A61P9/10;C12N5/0789 |
主分类号 |
A61K35/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|