发明名称 |
Recombinant attenuated clostridium organisms and vaccine |
摘要 |
<p>The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha -toxin. The expressed alpha -toxin is a deletion mutein that relative to the alpha -toxin of the mature alpha -toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His 68 . The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.</p> |
申请公布号 |
EP2368571(A1) |
申请公布日期 |
2011.09.28 |
申请号 |
EP20110157448 |
申请日期 |
2007.04.12 |
申请人 |
SCHERING-PLOUGH LTD. |
发明人 |
COCHRAN, MARK D.;PETERSON, GARY;LAIR, STEVEN V.;SYNENKI, RICHARD |
分类号 |
A61K39/08;A61K35/74;C07K14/33 |
主分类号 |
A61K39/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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