Systems and methods for rapidly changing the solution environment around sensors

摘要

The invention provides a method, in which a substrate is provided. The substrate comprises a chamber having a cell-based biosensor. The biosensor has a receptor which is activated by an agonist. Further, the substrate comprises a plurality of delivery channels delivering agonist, antagonist or buffer. Each channel comprises an outlet and delivers a substantially separate aqueous stream into the chamber. Further, each channel is in communication with a reservoir. The method further comprises selectively exposing the biosensor to a fluid stream from one or more channels.