发明名称 |
Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe |
摘要 |
A method of preparing a granulated pharmaceutical composition by wet granulation, which method comprises: (a) suspending one or more pharmaceutically active ingredients comprising statin or ezetimibe or both statin and ezetimibe in a granulating liquid to form a granulating suspension; (b) optionally subjecting the granulating suspension of step (a) to high pressure homogenisation; (c) adding the granulating suspension of step (a) or (b) to a composition comprising one or more pharmaceutically acceptable inactive ingredients; and (d) granulating the mixture of step (c), as well as pharmaceutical compositions obtained by this process.
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申请公布号 |
EP2368543(A1) |
申请公布日期 |
2011.09.28 |
申请号 |
EP20100157859 |
申请日期 |
2010.03.25 |
申请人 |
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO |
发明人 |
VRECER, FRANC;GERMAN, TAMARA;BUKOVEC, POLONA |
分类号 |
A61K9/16;A61K9/20;A61K31/397;A61K31/405 |
主分类号 |
A61K9/16 |
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