ACTIVATED POLYOXAZOLINES AND COMPOSITIONS COMPRISING THE SAME
摘要
The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.
申请公布号
EP2134181(A4)
申请公布日期
2011.09.28
申请号
EP20080726203
申请日期
2008.02.28
申请人
SERINA THERAPEUTICS, INC.
发明人
HARRIS, J., MILTON;BENTLEY, MICHAEL, DAVID;YOON, KUNSANG;FANG, ZHIHAO;VERONESE, FRANCESCO, MARIA