Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
摘要
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.
申请公布号
EP2368573(A2)
申请公布日期
2011.09.28
申请号
EP20110159231
申请日期
2006.11.06
申请人
NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.
发明人
RAPPUOLI, RINO;O'HAGAN, DEREK;DEL GIUDICE, GIUSEPPE