| 发明名称 |
Modified VEGF-A with improved angiogenic properties |
| 摘要 |
The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
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| 申请公布号 |
US8025886(B2) |
申请公布日期 |
2011.09.27 |
| 申请号 |
US20060505100 |
申请日期 |
2006.08.15 |
| 申请人 |
VEGENICS PTY LTD |
发明人 |
ALITALO KARI;TAMMELA TUOMAS;KESKITALO SALLA;PAJUSOLA KATRI;JELTSCH MARKKU M.;YLA-HERTTUALA SEPPO;KARPANEN TERHI;ERIKSSON ULF;UUTELA MARKO J. T. |
| 分类号 |
A61K39/385;A61B17/10;A61F13/00;A61K38/24;A61K39/00;C07H21/04;C07K1/00;C12N5/00;C12N15/00;C12P21/06 |
主分类号 |
A61K39/385 |
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