发明名称 |
Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists |
摘要 |
The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.
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申请公布号 |
US8026218(B2) |
申请公布日期 |
2011.09.27 |
申请号 |
US20070760445 |
申请日期 |
2007.06.08 |
申请人 |
THE UNIVERSITY OF ARIZONA |
发明人 |
HRUBY VICTOR;NAIR PADMA;YAMAMOTO TAKASHI |
分类号 |
A61K38/06;A61P23/00;A61P25/04 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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