LOW-SUBSTITUTED HYDROXYPROPYLCELLULOSE AND SOLID PREPARATION COMPRISING THE SAME

摘要

Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1); Crystallinity % = Ic - Ia / Ic x 100
wherein Ic means a diffraction intensity at a diffraction angle 2¸ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2¸ of 18.5°.