EXTENDED RELEASE PELLET FORMULATION CONTAINING PRAMIPEXOLE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF

摘要

The invention relates to medicine, in particular to an pramipexole extended release pellet comprising: 1) a pellet core containing pramipexole and comprising an inert pellet core and first layer being an active ingredient or prepared by wet or melt extrusion, or melt granulation, and 2) a second layer being an extended release coating comprising at least one water-insoluble polymer and optionally a pore former, the resulting pellet having a pH- independent in vitro release characteristic.