| 发明名称 |
USE OF P2X7 PATHWAY FOR ASSESSING THE SENSITIVITY OF A SUBJECT TO A CANCER TREATMENT |
| 摘要 |
The present invention concerns methods for assessing the sensibility of a subject to an anticancer treatment, for screening compounds which are useful for treating a cancer and for determining the likelihood of a metastatic relapse in a subject. The methods are based on the finding that a non-functional P2X7-elicited NALP3 inflammasome pathway in a subject is indicative of a resistance to treatment. The invention further concerns methods for treating a cancer and for restoring the sensitivity of the subject to a cancer treatment. |
| 申请公布号 |
US2011229411(A1) |
申请公布日期 |
2011.09.22 |
| 申请号 |
US200813131154 |
申请日期 |
2008.11.27 |
| 申请人 |
INSTITUT GUSTAVE ROUSSY;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PARIS-SUD XI |
发明人 |
APETOH LIONEL;TESNIERE ANTOINE;GHIRINGHELLI FRANCOIS;ZITVOGEL LAURENCE;KROEMER GUIDO |
| 分类号 |
A61K49/00;A61K38/02;A61K38/12;A61K38/20;A61K38/21;A61K39/395;A61P35/00;C12Q1/02;C12Q1/37;C12Q1/68 |
主分类号 |
A61K49/00 |
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