DISRUPTED ADENOVIRUS-BASED VACCINE AGAINST DRUGS OF ABUSE
摘要
The invention is directed to an adenovirus-antigen conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus, as well as a conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus. The invention also provides a method of inducing an immune response against an antigen in a human using the aforementioned conjugates. The invention further provides an adeno-associated viral vector comprising a nucleic acid sequence which encodes an antibody directed against cocaine.
申请公布号
WO2011116189(A1)
申请公布日期
2011.09.22
申请号
WO2011US28815
申请日期
2011.03.17
申请人
CORNELL UNIVERSITY;CRYSTAL, RONALD G.;DE, BISHNU;HICKS, MARTIN;ROSENBERG, JONATHAN;KAMINSKY, STEPHEN M.
发明人
CRYSTAL, RONALD G.;DE, BISHNU;HICKS, MARTIN;ROSENBERG, JONATHAN;KAMINSKY, STEPHEN M.