| 发明名称 |
USE OF IL-23 AND IL-17 ANTAGONIST TO TREAT AUTOIMMUNE OCULAR INFLAMMATORY DISEASE |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease. <P>SOLUTION: The invention relates to new methods and drug products for treating autoimmune ocular inflammatory disease. The methods involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. The invention is based on the discoveries that (1) blocking interleukin-23 (IL-23) activity or interleukin-17 (IL-17) activity prevents induction of EAU; (2) after induction, neutralization of IL-17 activity inhibits or reverses progression of EAU, but neutralization of IL-23 activity has little to no effect; and (3) IL-17 activity is not necessary for induction of EAU. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
| 申请公布号 |
JP2011184466(A) |
申请公布日期 |
2011.09.22 |
| 申请号 |
JP20110143593 |
申请日期 |
2011.06.28 |
| 申请人 |
SCHERING CORP;GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH & HUMAN SERVICES CENTERS FOR DISEASE CONTROL &PREVENTION |
发明人 |
CUA DANIEL J;KASTELEIN ROBERT A;TSAI VAN T;CASPI RACHEL;SILVER PHYLLIS;LUGER DROR |
| 分类号 |
A61K45/00;A61K39/395;A61K45/06;A61P27/02;A61P29/00;A61P37/06;A61P43/00 |
主分类号 |
A61K45/00 |
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