IMPROVED DELIVERY OF SUBMICROMETER AND NONOMETER AEROSOLS TO THE LUNGS USING HYGROSCOPIC EXCIPIENTS OR DUAL STREAM NASAL DELIVERY
摘要
Pharmaceutically engineered aerosols (e.g. submicrometer and nano- particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth- throat regions and near 100% deposition of the aerosol in the lung. Targeting of the aerosol to specific lung depths is also possible. In addition, methods and apparatuses for delivering aerosols to the lung are provided. The aerosol is delivered to one nostril of a patient while a relatively high humidity gaseous carrier is delivered to the other nostril, resulting in post-nasopharyngeal growth of the aerosol to a size that promotes deposition in the lung.
申请公布号
WO2011057235(A3)
申请公布日期
2011.09.22
申请号
WO2010US55940
申请日期
2010.11.09
申请人
VIRGINIA COMMONWEALTH UNIVERSITY;LONGEST, PHILIP, WORTH;HINDLE, MICHAEL