COMBINATION THERAPY FOR TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR TREATMENT OF CONDITIONS AMELIORATED BY INCREASING BLOOD GLP-1 LEVEL

摘要

PROBLEM TO BE SOLVED: To provide a new approach to lowering a blood glucose level in a subject and to increasing a blood GLP-1 level in a subject.

SOLUTION: The invention relates to combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level in a subject or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

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