MUTANT YEAST AND METHOD FOR PRODUCING SQUALENE USING SAME

摘要

The present invention relates to a method for producing squalene using mutant yeast which is produced by inducing a vector that expresses a HMG-CoA reductase (hydroxymethylglutaryl CoA reductase) and a farnesyl pyrophosphate synthase. More specifically, the present invention relates to a method for producing squalene with high efficiency by culturing the mutant and Y2805 mutant yeast in Saccharomyces cerevisiae that was transformed into a vector which includes the HMG1 gene, and ispA or Erg20 gene.