发明名称 |
COMPOSITION FOR THE ANTI-CANCER METASTASIS CONTAINING DLK1-FC FUSION PROTEIN AS AN EFFECTIVE INGREDIENT |
摘要 |
The present invention involves the construction of a recombinant expression vector involving combination of an IgG antibody Fc domain gene in a receptive domain gene of the extracellular region of DLK1, and the expression and purification of DLK1-Fc fusion protein in 293E cells, and the DLK1-Fc fusion protein has been confirmed to markedly reduce cancer cell migration and to be efficacious as a drug for a concept for practical cancer metastasis suppression through pharmacokinetic parameter calculation. The present invention can be used advantageously as an active ingredient in a composition for inhibiting cancer metastasis since DLK1-Fc fusion protein is more stable than non-fusion protein, markedly reduces migration in various cancer cell strains, and has an outstanding metastasis-inhibiting effect even at low concentration. |
申请公布号 |
CA2792413(A1) |
申请公布日期 |
2011.09.22 |
申请号 |
CA20102792413 |
申请日期 |
2010.04.13 |
申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
PARK, YOUNG WOO;JO, KIWON;LEE, DONGHEE;YU, JUNG;PARK, JI HYUN;PARK, CHAN-WOONG;KIM, EUN JIN;PARK, YUN JUNG |
分类号 |
C07K14/475;C07K19/00;C12N15/62;C12N15/63 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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