发明名称 |
IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION |
摘要 |
A screening method for identifying compounds that alter the fidelity with which the initiation codon in mRNAs is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. Methods of altering the fidelity of initiation codon selection are also disclosed. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed.
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申请公布号 |
US2011230451(A1) |
申请公布日期 |
2011.09.22 |
申请号 |
US201113051610 |
申请日期 |
2011.03.18 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
LORSCH JON R.;TAKACS JULIE ELLEN;NEARY TIMOTHY BRIAN |
分类号 |
A61K31/655;A61K31/4412;A61K31/47;A61K31/472;A61K31/473;A61P3/00;A61P7/00;A61P7/06;A61P31/10;A61P33/00;A61P35/00;C12N5/071;C12Q1/02;C12Q1/66 |
主分类号 |
A61K31/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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