发明名称 |
dsRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTION |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
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申请公布号 |
US2011230546(A1) |
申请公布日期 |
2011.09.22 |
申请号 |
US201113116947 |
申请日期 |
2011.05.26 |
申请人 |
BENSON JOHN;BRAMLAGE BIRGIT;FITZGERALD KEVIN;TAN PAMELA;VORNLOCHER HANS-PETER |
发明人 |
BENSON JOHN;BRAMLAGE BIRGIT;FITZGERALD KEVIN;TAN PAMELA;VORNLOCHER HANS-PETER |
分类号 |
A61K31/713;A61P31/20;C07H21/02;C12N5/02;C12N5/10;C12N15/113;C12N15/63 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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