发明名称 |
SYNDECAN-4 IS A REGULATOR OF RAC1-GTP |
摘要 |
The present invention provides a method for modulating the activity of Rac1, comprising modifying the phosphorylation state of Ser179 in syndecan-4 through influencing the interaction between syndecan-4 and the guanin nucleotide exchange factor of Rac1 (RacGEF) named Tiam1 in a GTP-dependent manner. In particular, methods are provided for enhancing the epithelial phenotype of a cell and for initiating the polarization of a cell by increasing the de-phosphorylation of said Ser179 of syndecan-4, and for enhancing the migratory phenotype of a cell and for initiating the neuronal differentiation of a cell by increasing the phosphorylation of said Ser179 of syndecan-4. Polypeptides for use in modulating the activity of the small GTPase Rac are also provided, as well as a method for identifying an agent capable of indirectly modulating the activity of the small GTPase Rac 1. |
申请公布号 |
EP2365984(A1) |
申请公布日期 |
2011.09.21 |
申请号 |
EP20090786696 |
申请日期 |
2009.07.24 |
申请人 |
SZILAK LABORATORIES BIOINFORMATICS & MOLECULE-DESIGN LTD. |
发明人 |
SZILAK, LASZLO;KELLER-PINTER, ANIKO;LETOHA, TAMAS;TIMAR, JOZSEF |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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