OLIGONUCLEOTIDE - FACILITATED COALESCENCE

摘要

Cells, liposomes and lipid particles are provided with complementary projecting oligonucleotides, which hybridize to bring them together as an aid to efficient fusion, which may be further aided by osmotic or electrical shock. The invention further provides complementary pairs of oligonucleotides containing moieties to anchor them in cellular and liposome membranes, as well as liposomes that carry agents to be introduced into cells and that are provided with membrane-bound projecting oligonucleotides.