发明名称 |
PHARMACEUTICAL PREPARATION OF RECOMBINANT FACTOR VIII LYOPHILIZED WITHOUT ALBUMIN AS A STABILIZER |
摘要 |
Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.
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申请公布号 |
CA2504377(C) |
申请公布日期 |
2011.09.20 |
申请号 |
CA20052504377 |
申请日期 |
2005.04.14 |
申请人 |
GREEN CROSS HOLDINGS |
发明人 |
PAIK, SANG-HOON;SHIN, YONG-NAM;KIM, JEAN-MAN;HUH, JAE-WOOK;LEE, JUNG-SIK;KWON, KI-SUNG;CHUN, JI-HYUN |
分类号 |
A61K38/16;A61K38/37;A61K9/19;A61K47/18;A61P7/04;C07K14/755 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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