发明名称 |
ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEINS |
摘要 |
Disclosed are compositions and methods for enhancing the circulating half-life of antibody-based fusion proteins. Disclosed methods and compositions rely on altering the amino acid sequence of the junction region between the antibody moiety and the fused protein moiety in an antibody-based fusion protein. An antibody-based fusion protein with an altered amino acid sequence in the junction region has a greater circulating half-life when administered to a mammal. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal. |
申请公布号 |
CA2399832(C) |
申请公布日期 |
2011.09.20 |
申请号 |
CA20012399832 |
申请日期 |
2001.02.09 |
申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES, STEPHEN D.;BURGER, CHRISTA;LO, KIN MING |
分类号 |
A61K39/44;C07K19/00;A61K47/48;C07K5/103;C07K14/47;C07K14/52;C07K14/525;C07K14/55;C07K14/705;C07K16/00;C07K16/18;C07K16/28;C07K16/30;G01N33/68 |
主分类号 |
A61K39/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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