发明名称 |
COMPOSITIONS AND METHODS FOR CHARACTERIZING BREAST CANCER |
摘要 |
The invention provides compositions and methods for characterizing breast cancer stem In particular, the invention provides for the identification of cells expressing Twist and CD44 that express little or virtually undetectable levels of CD24 (i.e. a Twist+/CD44+/CD24-/low cell sub-population). The presence of such cells in a breast cancer specimen identifies the breast cancer as having increased metastic potential. Such cancers are identified as requiring aggressive therapies. Accordingly, the invention provides biomarkers suitable for identifying, diagnosing, and monitoring treatment of a subject with breast cancer. |
申请公布号 |
WO2011113047(A2) |
申请公布日期 |
2011.09.15 |
申请号 |
WO2011US28358 |
申请日期 |
2011.03.14 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;RAMAN, VENU;VESUNA, FARHAD |
发明人 |
RAMAN, VENU;VESUNA, FARHAD |
分类号 |
G01N33/68;A61K31/7088;A61P35/00;C12N5/095;C12Q1/68;G01N33/574 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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