INDUCTIVE PRODUCTION OF PLURIPOTENT STEM CELLS USING SYNTHETIC TRANSCRIPTION FACTORS

摘要

The invention relates to a synthetic factor and the use of the synthetic factor in reprogramming somatic cells to induced pluripotent stem cells and other cell lineages. Concretely, the application relates to the fusion protein comprising the protein coded by cell totipotency related genes and the transcriptional regulatory domain, the coding sequence, expression vector and composition thereof. The application also relates to the method of reprogramming somatic cells to induced pluripotent stem cells and other cell lineages and the cells comprising the said fusion protein and the coding sequence.