发明名称 |
Type I Interferon Antagonists |
摘要 |
Disclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-1 such that the binding affinity of the interferon to the IFNAR-1 subunit is reduced as compared to the native interferon, and corresponding compositions and methods of treatment thereof.
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申请公布号 |
US2011224407(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US200913063108 |
申请日期 |
2009.09.09 |
申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
LANGER JEROME;SCHREIBER GIDEON |
分类号 |
C07K14/555 |
主分类号 |
C07K14/555 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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