TREATMENT OF STREPTOCOCCAL INFECTIONS

摘要

The present invention discloses a method of treating or preventing a Streptococcus pneumoniae infection wherein the Streptococcus pneumoniae infection occurs in an environment where the free concentration of Zn2+ and/or Mn2+ is sufficiently low to upregulate the expression of at least one PhtX protein (for example PhtD) in the Streptococcus pneumoniae; comprising the step of administering a pharmaceutically effective amount of the PhtX protein to a human patient.