发明名称 |
HIGHLY PURE VARENICLINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF SUBSTANTIALLY FREE OF METHYLVARENICLINE IMPURITY |
摘要 |
<p>Provided herein is an impurity of varenicline, 6-methyl-5,8,14-triazatetracyclo[l 0.3.1.02'n,04'9]hexadeca-2(l l),3,5,7,9-pentaene (methylvarenicline) impurity, and a process for the preparation and isolation thereof. Provided further herein is a highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity, a process for the preparation thereof, and pharmaceutical compositions comprising highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity.</p> |
申请公布号 |
WO2011110954(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
WO2011IB00983 |
申请日期 |
2011.03.08 |
申请人 |
ACTAVIS GROUP PTC EHF;PRADHAN, NITIN, SHARADCHANDRA;KUMAR, ARVAPALLY, SESHU;TRIVEDI, NIKHIL;SHARMA, KRISHNADATT |
发明人 |
PRADHAN, NITIN, SHARADCHANDRA;KUMAR, ARVAPALLY, SESHU;TRIVEDI, NIKHIL;SHARMA, KRISHNADATT |
分类号 |
C07D471/08;A61K31/4985;A61P25/34 |
主分类号 |
C07D471/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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