发明名称 |
Asthma Associated Factors as Targets for Treating Atopic Allergies Including Asthma and Related Disorders |
摘要 |
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAF1 gene products in one individual.
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申请公布号 |
US2011224153(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US20100762532 |
申请日期 |
2010.04.19 |
申请人 |
LEVITT ROY CLIFFORD;MALOY W LEE;KARI U PRASAD;NICOLAIDES NICHOLAS C |
发明人 |
LEVITT ROY CLIFFORD;MALOY W. LEE;KARI U. PRASAD;NICOLAIDES NICHOLAS C. |
分类号 |
A61K38/10;G01N33/53;A61K;A61K31/00;A61K31/13;A61K31/145;A61K31/70;A61K31/7088;A61K38/00;A61K39/395;A61K48/00;A61P11/00;A61P11/06;C07K;C07K7/08;C07K14/54;C07K14/715;C07K16/24;C07K16/28;C12N;C12N1/21;C12N5/10;C12N15/09;C12N15/24;C12P21/02;C12P21/08;C12Q;C12Q1/68;C12R1/19;C12R1/91;G01N |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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地址 |
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