The present invention relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. Chimeric fHbp (factor H binding protein) proteins and compositions comprising said proteins are described to overcome the problem of immune responses to fHbp being specific to the meningococcal strain from which the fHbp was derived.
申请公布号
CA2792683(A1)
申请公布日期
2011.09.15
申请号
CA20112792683
申请日期
2011.03.10
申请人
GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人
CASTADO, CINDY;DEVOS, NATHALIE ISABELLE;POOLMAN, JAN;WEYNANTS, VINCENT