ADDITION SALTS OF TROMETHAMINE WITH AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS.

摘要

The present invention is directed to novel crystalline addition salts of (i) tromethamine with (ii) an azabiphenylaminobenzoic acid derivatives of formula (I) wherein R1 is selected from the group consisting of C1-C4 alkyl, C3-C4 cycloalkyl and -CF3, G1 is selected from nitrogen atoms and CH, C(CH3) and C(CF3) groups, and G2 represents a phenyl group optionally substituted with one or two substituents selected from chloro, fluoro, methoxy, ethoxy, isopropoxy, trifluoromethoxy, CF3, and -CONR7R8, wherein R7 is hydrogen and R8 is cyclopropyl or R7 and R8 together with the nitrogen atom to which they are attached form a group of formula (IA) wherein n is 1. and pharmaceutically acceptable solvates thereof.