发明名称 |
BEAD BOUND COMBINATORIAL OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER LIBRARIES |
摘要 |
The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.
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申请公布号 |
US2011224099(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US201113046531 |
申请日期 |
2011.03.11 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GORENSTEIN DAVID G.;LUXON BRUCE A.;HERZOG NORBERT;YANG XIAN BIN |
分类号 |
C40B40/06;C07H19/00;C07H21/00;C12N;C12N1/00;C12Q1/68;C40B60/14;G01N33/53;G01N33/543;G01N33/68 |
主分类号 |
C40B40/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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