发明名称 |
COMBINE USE OF PTEROSTILBENE AND QUERCETIN FOR THE PRODUCTION OF CANCER TREATMENT MEDICAMENTS |
摘要 |
The invention relates to the combined use of pterostilbene and quercetin for the production of cancer treatment medicaments. The in vitro growth of melanoma cells B16-F10 (B16M-F10) is inhibited (56%) by combined exposures of short duration (60 min/day) to PTER (40 μM)+QUER (20 μM) (˜average values of plasma concentrations measured within the first hour following the IV administration of 20 mg of each polyphenol/kg ˜). The combined intravenous administration of PTER+QUER (20 mg/kg×day) to mice inhibits (73%) the metastatic growth of melanoma B16M-F10 in the liver, a common site for metastasis development. The invention demonstrates that the combination of PTER+QUER inhibits the growth of malignant melanoma metastasis and prolongs the survival of the carrier host.
|
申请公布号 |
US2011224290(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US20050631912 |
申请日期 |
2005.07.19 |
申请人 |
ESTRELA ARIQUEL JOSE MARIA;ASENSIO AGUILAR GREGORIO;ASENSI MIRALLES MIGUEL ANGEL;OBRADOR PLA ELENA;VAREA MUNOZ MARIA TERESA;JORDA QUILIS LEONARDO;FERRER PASTOR PAULA;SEGARRA GUERRERO RAMON;ORTEGA VALERO ANGEL;BENLLOCH GARCIA MARIA |
发明人 |
ESTRELA ARIQUEL JOSE MARIA;ASENSIO AGUILAR GREGORIO;ASENSI MIRALLES MIGUEL ANGEL;OBRADOR PLA ELENA;VAREA MUNOZ MARIA TERESA;JORDA QUILIS LEONARDO;FERRER PASTOR PAULA;SEGARRA GUERRERO RAMON;ORTEGA VALERO ANGEL;BENLLOCH GARCIA MARIA |
分类号 |
A61K31/352;A61P35/00 |
主分类号 |
A61K31/352 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|