TRANSGENIC MOUSE HAVING HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) PHENOTYPE, EXPERIMENTAL USE AND APPLICATION

摘要

PROBLEM TO BE SOLVED: To provide a transgenic mouse having human major histocompatibility complex phenotype and a cell.

SOLUTION: The present invention relates to transgenic mice, isolated transgenic mouse cells, and methods of using the mouse, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cells are deficient for both H2 class I and class II molecules, wherein the transgenic mouse comprises a functional HLA class I transgene and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cell has the genotype HLA-A2+HLA-DR1+β2m°IAβ°.

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