发明名称 |
DESIGNED ARMADILLO REPEAT PROTEINS |
摘要 |
The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections.
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申请公布号 |
US2011224100(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US20080733836 |
申请日期 |
2008.09.21 |
申请人 |
PARMEGGIANI FABIO;PELLARIN RICCARDO;LARSEN ANDERS PETER;VARADAMSETTY GAUTHAM;STUMPP MICHAEL TOBIAS;PLUECKTHUN ANDREAS |
发明人 |
PARMEGGIANI FABIO;PELLARIN RICCARDO;LARSEN ANDERS PETER;VARADAMSETTY GAUTHAM;STUMPP MICHAEL TOBIAS;PLUECKTHUN ANDREAS |
分类号 |
C40B40/08;C07K1/14;C07K14/435;C40B40/10 |
主分类号 |
C40B40/08 |
代理机构 |
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代理人 |
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地址 |
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