RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
摘要
Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
申请公布号
WO2011111034(A1)
申请公布日期
2011.09.15
申请号
WO2011IL00082
申请日期
2011.01.25
申请人
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;PILPEL, YITZHAK;TULLER, TAMIR;NAVON, SIVAN;RUBINSTEIN, MENACHEM