| 摘要 |
Disclosed are method of inhibiting or preventing bacterial aggregation or biofilm formation that involve use of (a) an antibody or fragment thereof that binds to an epitope within an amino acid sequence selected from the group consisting of (i) an amino acid sequence that has at least 90% identity to SEQ ID NO: 1 (BR domain of PsrP), (ii) an amino acid sequence that has at least 90% identity to SEQ ID NO:2 (NR domain of SraP), and (iii) an amino acid sequence that has at least 90% identity to SEQ ID NO:3. These methods find particular application in the treatment or prevention of bacterial disease associated with bacterial aggregation, such as empyema and pneumococcal disease. Related kits, vaccines, and compositions are disclosed. |
