GAMMA IRRADIATION OF SOLID NANOPARTICULATE ACTIVE AGENT

摘要

PROBLEM TO BE SOLVED: To provide methods for terminal sterilization of solid forms of nanoparticulate active agent compositions via gamma irradiation.

SOLUTION: The nanoparticulate active agent has an effective average particle size of less than about 2 microns, prior to incorporation into a solid form for sterilization. The gamma radiation is applied in a range of about 5 to about 50 kGray for the terminal sterilization. The resultant sterilized compositions exhibit excellent redispersibility, homogeneity, and uniformity. Also methods of treating animals and humans using such compositions are provided.

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