OLIGOMERIC COMPOUNDS FOR THE MODULATION OF HIF-1A EXPRESSION

摘要

Oligonucleotides directed against the hypoxia-inducible factor-1α(HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1αexpression and for the treatment of diseases associated with the hypoxia-inducible factor-1αare provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.