MRNA AS BIOMARKERS FOR LIVER INJURY OR OTHER LIVER PERTURBATIONS
摘要
The present invention provides a method for assessing the likelihood or for detecting the presence of liver perturbation in an individual. The method is particularly useful for detecting drug-induced liver injury (DILI) or other forms of hepatotoxicity or hepatic perturbation. The method comprises measuring the level of at least one RNA biomarker comprising mRNA and comparing the measured level to an appropriate reference value for the sample type and RNA biomarker type, and wherein a significant difference between the measured level and the reference value is indicative of liver perturbation.
申请公布号
WO2011112397(A2)
申请公布日期
2011.09.15
申请号
WO2011US26774
申请日期
2011.03.02
申请人
THE HAMNER INSTITUTES;THOMAS, RUSSELL, S.;WETMORE, BARBARA, A.