发明名称 |
LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF |
摘要 |
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
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申请公布号 |
US2011223147(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US20090991104 |
申请日期 |
2009.05.07 |
申请人 |
ZYSTOR THERAPEUTICS, INC. |
发明人 |
LEBOWITZ JONATHAN H.;MAGA JOHN |
分类号 |
A61K38/43;A61P43/00;C07H21/00;C12N1/00;C12N5/10;C12N9/96 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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