摘要 |
A METHOD OF PRODUCING AMIDE ESTER DERIVATIVE OF AZELAIC ACID COMPRISING TREATING AN AMINO ACID HYDROHALIDE OF THE GENERAL FORMULA, WHEREIN R' AND R" ARE EACH ALKYL GROUP MOIETY AND SIDE CHAIN GROUP OF THE AMINO ACID BOTH SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED ALKYL MOIETY, CYCLIC ALKYL OR AROMATIC MOIETY TO BE DISSOLVED IN AN APROTIC SOLVENT WITH AN ORGANIC BASE TO EFFECT DEPROTONATION, REACTING THE DEPROTONATED PRODUCT WITH AN AZELAIC ACID HALIDE ALSO DISSOLVED IN AN APROTIC SOLVENT, CONTACTING THE REACTANT MIXTURE WITH AN ANHYDROUS SALT TO REMOVE ANY MOISTURE THEREFROM AND REMOVING THE APROTIC SOLVENT FROM THE REACTANT MIXTURE.
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